Anthropometric features and body composition of young athletes practicing karate at a high and medium competitive level

The aim of the study was to examine the anthropometric features and body composition of athletes practising karate at a high and medium competitive level. Our study was carried out on a sample of 35 subjects practising karate and aged from 16.0 to 32.5 years. This sample was divided into two groups: group 1 (n=14 elite athletes) and group 2 (n=21 amateur athletes). Various anthropometric measurements were taken (weight, height both standing and sitting, diameters, circumferences and skinfold thickness) from which different anthropometric indices were calculated (body mass index, Scelic and Grant indices, arm muscle circumference and area), and the somatotype was then determined. The body composition of each subject was assessed using the skinfold technique and the Jackson-Pollock (J-P) and Sloan-Weir (S-W) equations. The two groups of athletes showed very similar measurements regarding anthropometric characteristics. Only the Scelix index presented a significantly different value in the two groups (49.6±1.3 for group 1 vs. 51.1±1.3 for group 2; p<0.01). Group 1 showed a mesomorphic-ectomorphic somatotype, while the amateur athletes presented a balanced mesomorphic type. Moreover, a lower percentage of fat mass was more frequent in the first group (J-P=8.1±2.4%; S-W=8.9±3.3%) than in the second one (J-P=9.8±1.6%; S-W=11.2±3.7%), although the differences between the two groups were not significant. We conclude that group 1 is characterized by a slightly prominent vertical development of the skeletal frame. This could be an anthropometric characteristic that is best suited to meet the specific functional requirements of this sport. Moreover, both groups of athletes are characterized by a low percentage of fat mass, particularly the elite group

Cholesterol impairment contributes to neuroserpin aggregation

Intraneural accumulation of misfolded proteins is a common feature of several neurodegenerative pathologies including Alzheimer's and Parkinson's diseases, and Familial Encephalopathy with Neuroserpin Inclusion Bodies (FENIB). FENIB is a rare disease due to a point mutation in neuroserpin which accelerates protein aggregation in the endoplasmic reticulum (ER). Here we show that cholesterol depletion induced either by prolonged exposure to statins or by inhibiting the sterol regulatory binding-element protein (SREBP) pathway also enhances aggregation of neuroserpin proteins. These findings can be explained considering a computational model of protein aggregation under non-equilibrium conditions, where a decrease in the rate of protein clearance improves aggregation. Decreasing cholesterol in cell membranes affects their biophysical properties, including their ability to form the vesicles needed for protein clearance, as we illustrate by a simple mathematical model. Taken together, these results suggest that cholesterol reduction induces neuroserpin aggregation, even in absence of specific neuroserpin mutations. The new mechanism we uncover could be relevant also for other neurodegenerative diseases associated with protein aggregation.Comment: 7 figure

Definition of ecological flow using iha and iari as an operative procedure for water management

It is widely recognized that the hydrological regime of natural flow plays a primary and crucial role in influencing the physical condition of habitats, which, in turn, determines the biotic composition and sustainability of aquatic ecosystems. The current hydro‐ecological understanding states that all flow components might be considered as operational targets for water management, starting from base flows (including low flows) to high and flood regimes in terms of magnitude, frequency, duration, timing, and rate of change. Several codes have been developed and applied on different case studies in order to define common tools to be implemented for Eflow assessment. This work deals with the definition of an operative procedure for the evaluation of the Eflow monthly distribution to be adopted in a generic watercourse cross‐section for sustainable surface water resource management and exploitation. The methodology proposes the application of the Indicators of Hydrologic Alteration methodology (IHA by TNC) coupled to the valuation of the Index of Hydrological Regime Alteration (IARI by ISPRA) as an operative tool to define the ecological flow in each monitoring cross‐section to support sustainable water resource management and planning. The case study of the Agri River in Basilicata (Southern Italy) is presented. The analyses were carried out based on monthly discharge data derived by applying the HEC‐Hydrological Modeling System at the basin scale using the daily rain data measurements obtained by the regional rainfall gauge stations and calibrated through the observed inlet water discharge registered at the Lago del Pertusillo reservoir station

Robust information for effective municipal solid waste policies : identifying behaviour of waste generation across spatial levels of organization

Unidad de excelencia María de Maeztu CEX2019-000940-MExisting studies have studied influencing factors of MSW generation behaviour at different spatial levels of organization, but always one at a time and not simultaneously. Income is a strong influencing factor, affecting MSW generation from the individual to the country level, capable of hiding the effects of the others. This study shows that when MSW generation behaviour is holistically analysed across multiple levels of organization (individuals, households, and communities) hierarchically organized as functional units of MSW generation within a specific study area, it is possible to identify influencing factors in addition to income (education, demographic, health, ethnic, economic activity and financial types) as explanatory variables. Increasing the number of influencing factors of MSW generation makes it possible to create a robust knowledge base for MSW management policies in fast-growing urban areas of developing countries, improving the information used to select proper policies and plans within their MSW management systems and avoiding overlapping policies causing legal gaps. Betania, an urban area of the Panama City district, has been chosen as a case study area. The results show that the household income explains 86% of its memberś MSW generation and the community indigenous population explains 21% of householdś MSW generation. It is concluded that MSW generation is not linear across levels, it has as many degrees of freedom as influencing factors shaping the levels of organization where functional units generating waste exist. Influencing factors appearing at each spatial level affects MSW generation in an interdependent manner in variable degrees of magnitude

Beta-Gamma science for sustainable agriculture: taking the implications of complexity seriously

Life is the interaction of non-equivalent observers guided by different but legitimate goals and non-reducible models of each other.This implies that when studying the evolution of living systems and the sustainability of human progress it is impossible to define in substantive terms "optimal solutions" or "best courses of action". In fact, these concepts do entail a set of pre-analytical ideological decisions: "best" or "optimum" for whom? On which time scale? In relation to which selection of attributes of performance? Who should decide about this?When coming to the availability of hard data to study sustainability things do not get easier. Empirical information is generated by a mix of abstractions about reality (the definition of the identity for the modeled systems, which is associated with a finite set of categories - variables - adopted in the model) and real signals from reality (those found when operating the selected measurement scheme). Therefore, empirical information should not necessarily be considered more "substantive" than the information provided by philosophers or informed actors.In spite of this epistemological impasse, hard scientists do not have alternatives to the old reductionistic agenda of "reduzieren" and "classifizieren" (they can only adopt one formal narrative at the time). They can only base their representations of reality on a finite set of models with which it is possible to simulate patterns of behaviours validated in the past. These models obviously do not evolve in time.The complexity revolution provides a way out of this impasse. To provide useful information to societal processes of decision making about sustainability scientists can: (i) use simultaneously non-equivalent relevant narratives referring to different scientific disciplines and different scales. This implies adopting integrated packages of models able to reflect useful perspectives and relevant mechanisms (Multi-Scale Integrated Analysis); and (ii) get involved in a process of evaluation which is multicriterial and participatory. This implies the requirement of adding a "quality assurance control" to the process of decision making based on scientific information (Societal-Multi-Criteria-Evaluation).Innovative concepts derived from complex systems thinking [e.g. learning holarchies, mosaic effects across scales, impredicative loop analysis, useful narratives to surf complex time] can be used to enlarge the repertoire of analytical tools available for analysis of sustainability. When using these concepts it becomes possible to look for meta-models (useful metaphors and narratives) when choosing a scientific problem structuring, rather than relying solely on statistical tests and differential equations.In the final part of the thesis, practical examples of applications are discussed to show that the adoption of these innovative concepts can actually help in developing useful analyses of the sustainability of agriculture. Principal applications refers to: (1) the definition of a mechanism of benchmarking for typologies of societal metabolism. This method of analysis can be used to define typologies of farming systems. This typologies make it possible to infer typologies of constraints that the socio-economic context entail on farming systems. (2) the establishment of a bridge between the characteristics of the farming systems and typologies of ecological impact on terrestrial ecosystems. (3) an analysis of farming systems seen as nested hierarchical systems. In this case, different agents operating at different levels can be characterized on a multi-criteria performance, This implies that the various strategy matrices adopted at different levels can be effectively studied

Identification of inference fallacies in solid waste generation estimations of developing countries. A case-study in Panama

Altres ajuts: Acord transformatiu CRUE-CSICUnidad de excelencia María de Maeztu CEX2019-000940-MThe absence of sound sampling procedures and statistical analyses to estimate solid waste generation in many developing countries has resulted in incomplete historical records of waste quantity and composition. Data is often arbitrarily aggregated or disaggregated as a function of waste generators to obtain results at the desired spatial level of analysis. Inference fallacies arising from the generalization or individualization of results are almost never considered. In this paper, Panama, one of the fastest-growing developing countries, was used as a case-study to review the main methodological approaches to estimate solid waste generation per capita per day, and at different hierarchical levels (from households to the country). The solid waste generation intensity indicator is used by the Panamanian waste management authority to run the waste management system. It was also the main parameter employed by local and foreign companies to estimate solid waste generation in Panama between 2001 and 2008. The methodological approaches used by these companies were mathematically formalized and classified as per the expressions suggested by Subramanian et al. (2009). Seven inference fallacies (ecological, individualistic, stage, floating population, linear forecasting, average population and mixed spatial levels) were identified and allocated to the studies. Foreign companies committed three of the seven inference fallacies, while one was committed by the local entity. Endogenous knowledge played an important role in these studies to avoid spatial levels mismatch and multilevel measurements appear to produce more reliable information than studies obtained via other means

Research of non-specific hyperreactivity of upper airways in subjects with gastro-esophageal reflux (G.E.R.): Preliminary reports

An association between asthma and gastro-esophageal reflux (GER) is well recognized but the underlying mechanism is still unclear. The authors suggest that could exist an association between GER and upper airways hyperreactivity and this association could represents the mechanism underlying the lower esophageal sphincter releasing, that determine the reflux. In fact they suppose that, the noxious injury of acid reflux follows a course that could be: pharynx → larynx → bronchi → 1/3 inferior of the esophagus → reflux. From these presuppositions the authors carried out a study on the possible relationship between GER and non-specific hyperreactivity of upper airways on 14 subjects, divided in 2 groups: 10 subjects with functional GER, 4 subjects suffering from GER caused by hiatus hernia as control group. All patients had a thorough medical history, ENT examination with rigid and flexible endoscope, anterior Rhinomanometry (RRM), skin-test for inhalant and alimentary allergens, RAST, audiometric exam, non-specific nasal provocation test (NSNPT) with histamine, using as control the number of sneezes. From a through analysis of objective examination and from the results of the NSNPT with histamine resulted that all subjects with functional GER were rhinopathics. In all tests both in vivo (Skin-test) and in vitro (RAST) for the most common allergens (pollens-inhalant-mycophites-alimentary) the results were negative. The authors also found an involvement of paranasal sinuses that raised: 91% in the patients with recurrents phlogosis due to non specific nasal hyperreactivity; 40.9% in the allergic subjects (20% in the Graminacee +; 32% in the Parietaria O. +; 76% in the Dermatophagoides Pt. +; others 4%); 100% in the ASA-intollerance subjects. The NSNSPT with histamine showed in the group with functional GER a hyperreactivity with sneezes in 6/10 subjects, and 1/4 subjects of the group with GER with hiatus hernia. The RRM variations showed an unilateral nasal hyperreactivity in 6/10, bilateral in 3/10 subjects of the group with functional GER. In the group with GER with hiatus hernia only 1/4 subject showed reliable unilateral RRM variation. From the analysis of data resulted that subjects with functional GER showed a completely involvement of the upper airways and not only of the pharynx and larynx, caused by non specific hyperreactivity at the NSNPT with histamine, associated with a chronic pathology

Neural responses to facial and vocal expressions of fear and disgust

Neuropsychological studies report more impaired responses to facial expressions of fear than disgust in people with amygdala lesions, and vice versa in people with Huntington's disease. Experiments using functional magnetic resonance imaging (fMRI) have confirmed the role of the amygdala in the response to fearful faces and have implicated the anterior insula in the response to facial expressions of disgust. We used fMRI to extend these studies to the perception of fear and disgust from both facial and vocal expressions. Consistent with neuropsychological findings, both types of fearful stimuli activated the amygdala. Facial expressions of disgust activated the anterior insula and the caudate-putamen; vocal expressions of disgust did not significantly activate either of these regions. All four types of stimuli activated the superior temporal gyrus. Our findings therefore (i) support the differential localization of the neural substrates of fear and disgust; (ii) confirm the involvement of the amygdala in the emotion of fear, whether evoked by facial or vocal expressions; (iii) confirm the involvement of the anterior insula and the striatum in reactions to facial expressions of disgust; and (iv) suggest a possible general role for the perception of emotional expressions for the superior temporal gyrus